I have the full Banks PowerPack. It made a HUGE improvement in power.
A also re-geared to 4.56. This was the best upgrade for towing.
And I'm running a Diablo Predator. With the Banks and Predator together, the engine developed a nice secondary node around 4800 RPM, so I've raised the shift points and the electronic rev limiter to take advantage of that power.
I have the Banks transcommand. It did improve shift firmness, but not enough for my liking so i've bumped it up even further with the Predator. The transcomand also lowers the TC lockup point, which the Predator does not do (But I think it could with a custom tune).
I pulled the Banks Ottomind when I started using the Predator. I may try stacking them soon to see if it works. The Predator makes more high end power than the ottomind, but the Ottomind makes 100% of your mid-range power available on demand. The ECU retards power availability after downshifts (not just torque modulation for shifting... I think it may be part of the Low Emissions programming). Banks claims up to a minute, but I can sure feel it for the first 10 seconds.
So now I can pull an 18,000 pound trailer up a 6% grade at 65 MPH. All day. Heat is not an issue.
As for reliability... Spark plug life is shorter. Only good for about 70,000 miles now. But as for the motor... I just passed 257,000 miles and the engine and transmission are still like new. About 120,000 of that has been towing. About 50,000 has been with a combined weight over 20,000.
I don't have this trailer any more (broke the frame... with some help of from freezing rain and a guardrail), but fully loaded was over 18,000 pounds, length was 41')