Depends which engine and what sort of RPM's it likes. My experience, for consideration:
I have a GMC 6.6 Duramax with 5 speed Allison transmission with 3.73 gears and 285/75/R16's, compare to my Ford 6.0 Powerstroke with 5 speed transmission with 4.10 gears and 315/75/R17's.
The GMC turns ~2,200 RPM's at 75 mph, which is a little higher than necessary for that engine, which really performs well when lugged at low RPM; it red-lines ~3,500 RPMs.
The Ford turns ~2,200 RPM's at 75 mph, which is a little lower than the engine likes when pulling up even a slight hill or headwind; that engine redlines at 4,000+ RPMs and regularly winds up >3,500 RPMs when givin'er.
Both combinations perform very well in the CO mtns (two-lane highways with mountain passes at 55-65 mph), but I can't go deeper into comparison because it's apples