Drove through Titus Canyon for the first time on this trip to Death Valley. It's a rough road, but we did get passed by a Nissan Versa while having lunch if that tells you anything. There was beautiful scenery and I was amazed at the amount of wildflowers still in bloom.
2010 Red EB50 V10, Quadvan 4WD (El Guapo Rojo)
1978 VW Westfalia Champagne Edition (Pepe - gone, but not forgotten)
Depends on the conditions and your vehicle but I know people who have done it in a car. It can get slick when wet and sandy in other spots. That said I've seen 2wd vans travel on more difficult trails in DV. Having a compressor to air up after lowering the tire pressure would be worth having on board. The rangers will almost always tell you no, but you can drive up from where the trail exits and ask those who have come through what the condition are.