I'm thinking of taking your recommendation of up Mazurka Canyon and ultimately out Eureka/Saline Road. In looking over some maps, it looks like there are some missing connectors up top. Will the trails be obvious up there?
Get an Inyo National Forest map, that should show all the connectors. Be aware there are a lot of new areas of Wilderness designation, many roads are closed but the main ones do go thru.
Up Mazurka to Badger Flat. 4wd from Badger to Papoose flat (excellent place to camp). Papoose Flat to Squaw Flat. Down out of Squaw Flat via Marble canyon, out to the Eureka/Saline Valley Road.
Good deer and chukar hunting, and lots of artifacts, mining and prehistoric. Be careful of the mineshafts.
I would advise getting out of Squaw Flat via Marble Canyon NOT the Hinds road west of Andrews Mnt.
I would also advise against the Papoose Flat strait down to Harkless Flat route, easy but now closed.
Best hike in the area is Barrel Spring to Winneduma Paiute Monument out of Mazurka Canyon.