The whole Mt Jefferson area is currently a no-go, all the way up to and including the Clackamas River watershed. They're trying to get Ollalie lake open by July. There's a LOT of down trees, so it's really not passable on most routes, those that are clear have VERY heavy logging traffic.
South of Highway 22, it's all open. It's all doable in 2WD, but there's some gnarly sections near Summit lake. I wouldn't recommend some sections if its not dry. But there's still many workarounds that'll keep you off pavement.
Once you get closer to Mt. Hood, you get out of the fire affected zone again. There's plenty of VERY scenic alternate routes west and east of the PCOR so I wouldn't cancel your trip just because that one 50 mile section isn't passable.
2000 E450 dually V10 wagon