I'd ditto scotty's input. ~4yrs owning my self-converted van and have never had an issue with mold under the mattress (this includes 8 months of traveling/living out of it full time). My bed platform is plywood, so I drilled 3/4" holes in a pattern across most of it to allow for some ventilation. Mattress is a cheap-o foam mattress from amazon cut to size, DIY cotton/poly mattress cover (aka nothing fancy). Plywood is also raw, no protective paint. I leave the mattress in it 90% of the time (don't tip it up or anything).
There are obviously lots of fancy products that will help to avoid mold... but I haven't come across a need for them. Biggest risk IMO is when you don't use the van for a while and there's a small leak somewhere that you don't notice until it's too late... Always best to run a small dehumidifier or heater for a day or two every month at the very least if the van isn't getting used. Boats are definitely a different story... mold/moisture in them is a guarantee. Your van should be ok IMO.
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2003 E250 Full Self-Build
2009 Honda Element "lil' toaster"
2013 Suzuki DR650
Santa Cruz, CA
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