Originally Posted by Slick2Slide
That seems like a nice van as well. I can't tell from the add if it has the EB50 layout. The price is pretty much the same on the two. Does the 7.3 vs the 6.0 make up for the 11 year difference?
Ultimately while all vehicles can have that one part that breaks by chance and leaves you stranded in the middle of nowhere, the general consensus that I have gathered from lurking and talking to owners(family) of F-series 7.3, 6.0, and 6.4, is that the 7.3 is by quite some margin the cheapest to work on, and the most reliable.
I think most people in this community would probably agree that if you feel the 7.3L is down on power, that you can turn them up from factory ratings to about 300-325 and still retain some level of reliability.
Now, the case I would make for the 6.0L: If you happen to live, or otherwise have the ability to register this vehicle where it is smog exempt, and it has the ARP headstuds, good coolant, and an EGR delete, it might be OK. The 6.0's still tend to benefit from a lot of 6.4 parts, however. Deep oil pan, starters, etc.
Regarding the 11 year difference... Really the only thing I can think if that you'd be missing out on is that the 7.3L is going to use the 4R100 and the 6.0L is going to use the 5R110. once you get into the 2008's, you get the new front end and the good cupholders, and the 2009's, you get the new interior (Nothing is explicitly 'wrong' with the older interior, but I think you would, as well as many others have found that the interior door skins on '09+ are much more friendly to use, and I like the newer dashboard/tachometer).
I believe MY2010 was the last year for the 6.0 diesel E-series, and for 2011-2014, the "best" motor you could get was the 6.8L V10.
EDIT: I was going to just cut and paste some of what was said HERE
into this thread, but figured better just to give the link instead.
CarringB's comment of, "Well, even the newest 7.3L's are coming up on 17 years old..." and "It isn't necessarily the motor you have to worry about crapping out, it's everything connected to it!" does have a lot of truth to it. At the end of the day... both are pretty expensive. IMO that is why a lot of people chase down the V10's. Sure-they guzzle gas, but have plenty of power, are generally very reliable, and "cheap" (comparatively speaking) to work on. Food for thought.