Which motor? If it’s not a diesel, 4.10 is a good ratio for that tire size. Really the only downside of 4.10 is if you want to upgrade to a Dana 60 front axle in the future, it’s not a factory ratio on the super duty. They are pretty much 3.73 or 4.30. Or even taller on the newer axles.
I do definitely think the Dana 60 is a better way to upgrade your stopping power. There’s not much you can do with the D44.
2000 E450 dually V10 wagon