Really, total ride height (tire + suspension lift), and what's bolted the outside, have more affect than what motor it has.
3.73 gears are way too tall for 295 tires. That will require lots of torque converter work to launch from a stop, and it probably will struggle to stay in O/D on the highway, especially if it has a bumper or rack. Both of those issue will make lots of extra heat in the transmission.
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2000 E450 dually V10 wagon
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