You did not mention your wheel diameter, but...
My EB V-10 QuadVan has 4.10's and 33" tires.
QuadVan does not go lower unless you want them to do it. If you change out your rear gears at QV you lose your factory warranty (on diff gears) and only have QV's one year warranty on the diff gears. Front diff gears also get the one year warranty.
Diff gears are only as good (long lasting) as the installer doing the job (not that QV does a bad job).
With that said I pull a 22' 5500 lb trailer.
If you have 33" tires I would recommend 4.56 gears. My van is geared too high w/33's & 4.10's.
If I had 35" tires with a V-10 I would want 4.88's.
4.10's put you below your torque spread most off the time. First will rev out way to long and 4th & 5th are not used enough. You need more than 2200 rpm at 70, especially pulling a trailer where you probably wont be going 70 (ie even less rpm's).
IMO the V-10 4x4 van (w/33's) needs 4.56 even without pulling a trailer. As its known the V-10 works better revving it out.
Remember when you get 4.10's from the factory they are designed to operate with the stock sized tires (not 33's or 35's).
I have had several 4x4's re-geared over the years. Correct gearing is paramount for proper acceleration, pulling power and economy.
Before they were re-geared they were dogs...
Oh, while pulling my trailer I get 6-7 mpg.
I would guess the Ram diesel is superior in every way at pulling compared to the Ford gas V-10.