With about 200,000 miles on Open Country ATs and about 60,000 miles on M55s, I have only had 1 tire fail, and it did not fail completely. The OC/AT that failed blistered on the sidewall, but it was 500 pounds overloaded at the time, and is the reason my van is now a dually. Luckily, Les Schwabs are plentiful around here, so it only turned out to be a 20 minute delay while they swapped on a new tire (no charge of course). I also bent a steel wheel once when I was T-boned by Honda, but the tire was fine.
Since the van became a dually, I have broken 2 different wheels, but have not lost a tire.
And yes, the van does get pretty extensive off-road use, both low speed and high-speed.