First time poster and newish owner of a 1996 E250 extended (bought it in November, but just got back from the first big trip in it). We bought the van to use as a dirt bike and mountain bike hauler/minimal camper. We have it set up to carry two dirt bikes in the back (with front wheels turned to the sides), and a full size mattress width-wise in front of the bikes. The mattress is 53" wide, I would say the available space is about 55".
Regarding ease of driving, my daily is a 2020 Tacoma and the van is only a foot or so longer than my truck. It's as easy to drive and park as any truck. The main difficulty for me is not being able to see what's directly behind me when backing up, as anything below the rear door windows is blocked. A backup camera will remedy that.