All wheels from stock Econolines are interchangeable as they all have 8 x 6.5 inch lug pattern. When you get into 4x4 versions of teh vans things get a little more complicated as some 4x4 conversions utilize the 8 x 170 mm lug pattern.
Short answer is 2 wd, no issues. If 4wd check what you have and what you are getting.
Beastie 3: 2002 7.3 EB Cargo: Agile TTB, CCV Mid Top, Custom Walk Through, Lots of stuff added. BlingMyRig.com