I have pretty much your same setup - 265/75/16, 2wd, 7200-7500#. When I switched from 245 to 265 tires with the stock 3.73 rear axle, i experienced a pretty noticeable slow-down. Short highway on-ramps were especially dreadful. Switched to 4.10 gearing and it has made things a lot better. I would even consider going up another tire size when my current tires need replacing.
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2003 E250 Full Self-Build
2009 Honda Element "lil' toaster"
2013 Suzuki DR650
Santa Cruz, CA
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